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Spinal Cord Stimulation (SCS), Peripheral Nerve Stimulation (PNS), and Dorsal Root Ganglion (DRG) Stimulation
 

Neuromodulation is a proven therapy to manage chronic pain and improve quality of life.

Neuromodulation systems deliver electrical pulses to the spinal cord or peripheral nerves, modulating (changing) the transmission of pain signals to the brain.

Implantable neuromodulation processes include:

  • Spinal cord stimulation (SCS), where leads are placed in the epidural space adjacent to the sensory pathways
  • Peripheral nerve stimulation (PNS), where leads are placed in the region of a peripheral nerve
  • Dorsal root ganglion (DRG), where leads are placed near the dorsal root ganglion

These leads are connected to implantable pulse generators, which are known as IPGs.
 
 
Step 1: Trial Stimulation

An important feature of Neuromodulation is the ability to trial the therapy. This enables the patient to experience Neuromodulation and get a good indication of how much pain reduction is possible.

The trial involves a minor operation where leads are placed via an epidural Tuohy needle and connected to a temporary external stimulator. These leads are easily removed at the end of the trial.

 

Step 2: Implantation of Permanent System

If the trial is successful, the permanent procedure requires small incisions to implant the leads. A subcutaneous pocket is created in the abdomen or buttock area. The leads are connected to the IPG and secured in the pocket.

The patient is able to control the therapy with a wireless programmer.
 
Spinal Cord Stimulation (SCS)
 
What is it?

Spinal cord stimulation involves delivering a low voltage electrical impulse to the spinal cord to block the sensation of pain. The stimulation is provided by way of two small wires that are inserted into the spinal canal under x-ray control. These small wires are connected to a lead that runs around the side of the trunk to the stimulator unit itself, which is implanted into the fatty layer of the abdomen, deep to the skin.

The unit can be programmed to deliver either intermittent or continuous impulses to the spinal cord, which block the usual sensations of pain.

 

What is SCS used for?

It is a treatment generally reserved for severe intractable lower back and leg pains that have not responded to the usual conservative treatment.

 

Side effects and complications

SCS is generally a well-tolerated procedure with few long-term side effects. However, the following adverse reactions have been recorded:

  • Technical problems related to the implantation of the device may occur leading to leakage of spinal cord fluid, possible spinal nerve damage, or excessive bleeding at the site of surgery either anteriorly or posteriorly around the spinal cord.
  • Infection is quite uncommon, but when it does occur, it may involve the spinal canal. Symptoms usually involve fever, sweats, headaches, and increasing pain. Infection involving any foreign material inserted in the body requires that material usually to be removed and a course of anti-biotics given.
  • In the longer term, it is possible there may be malfunction of the hardware or loss of pain relief. The loss of pain relief may be due to either the body getting used to the stimulation (tolerance) or it’s possible that the wires may have moved and need to be re-sited. Due to movement of wires, some patients may experience uncomfortable jolting or sensations of electric shocks that occur with stimulation. Re-positioning of the wires usually rectifies this problem.
  •  
    Peripheral Nerve Stimulation (PNS)
     
    What is it?

    Peripheral nerve stimulation (PNS) is increasingly recognised as a safe, minimally invasive and easily reversible treatment for a variety of chronic pain conditions.

    The exact mechanism by which PNS works is unknown. However, the main theory is that the electrical current and magnetic fields from the stimulator block the firing of the nociceptive (pain) fibres in the area. Even a widespread area of pain can be generated from a relatively small area of nociceptive fibres.

     

    What is PNS used for?

    PNS is a treatment option for anyone with singular or multiple areas of relatively circumscribed pain. PNS can also be used even if the pain is over a more widespread area, as long as there is a more severe central area. Significant success has been reported for:

  • Low back pain – particularly for patients who have disabling back pain despite surgery or following other failed treatments such as radiofrequency neurotomy (5,6)
  • Headache -particularly occipital and high cervical spine (i.e. upper neck and back of head) (7-12), but also frontal (particularly around the eye and temple) including cluster headache and migraine, and also in association with fibromyalgia (15)
  • Trunk – particularly in narrow bands of pain (e.g. along old scars) (16)
  • Groin – particularly for patients who have ongoing pain after hernia repairs (17)
  • Other focal areas of pain: e.g. following shingles (18)
  •  
    Side effects and complications

    The main issue, as with any implantable device, is the risk of infection, although this appears to be less than five per cent and is not as serious or dangerous as it is for SCS. Often the infection can be simply controlled with antibiotics. If not, the system can be removed. PNS is considered to be safe than SCS in terms of neurological risk of complication. As anaesthetic agents are used, there is an exceedingly rare risk of serious complications, including brain injury and death.

    Similar to SCS, leads may move and need repositioning, or they may become damaged and fail to provide stimulation, or create unwanted spasms and irritation. Occasionally the leads perforate the skin, as they are placed just under the skin surface. This is rare, and requires temporary removal of the lead.

    The site can at times be tender to touch or can become swollen. The battery can fail earlier than predicted and need to be removed and replaced.
     
    Dorsal Root Ganglion (DRG) Stimulation
     
    What is it?

    Dorsal root ganglion stimulation is a form of neuromodulation, targeting the Dorsal Root Ganglion (DRG).

    The DRG plays a key role in modulating sensory input and is responsible for generating ectopic firing, increasing neuropathic pain after injury. Stimulation of the DRG can interrupt this process, preventing pain signals from travelling to the brain.

    What is DRG used for?

    DRG has been found to be beneficial to patients who suffer from:

  • complex regional pain syndrome (CRPS)
  • post-surgical groin pain (e.g. hernia repair)
  • post-surgical knee pain (e.g. knee replacement)
  • post-surgical hip pain (e.g. total hip joint replacement)
  • post-surgical foot and ankle pain
  • phantom limb pain(following amputation).
    •  

    • Recovery times vary among patients. The stimulation therapy will start to work within the first week following lead placement. The wounds will take one to two weeks to heal.
      Any discomfort from the stimulator placement will decrease over a two to three month period.
    • The patient must not shower or get incisions wet throughout the entire duration of the trial or up to seven days post permanent implant.
    • Patients can have all forms of imaging investigation except MRI’s at this time
    • Patients should avoid twisting, bending, stretching, or lifting anything heavier than five kilograms until the leads have healed in place.
    • These movements may cause the leads to move and possibly cause an unpleasant sensation.
    • Pain medication can be reduced once stimulation parameters have stabilized.

    Extra care will be required in the presence of cardiac pacemaker or the use of other implantable electrical devices. Following the insertion of the unit, patients will be made aware of precautions required with outside electrical equipment, such as diathermy.

    Other external devices that employ large magnets may also affect the unit and as such, care should be taken near magnetic fields such as close to arc welding equipment. If implanted with a stimulation system, you will be able to bypass through the security gate. You will be given a patient identification card after your implant. Show this card to the security officer before you enter a security gate. If requiring an MRI machine please speak with your physician as some devices are not compatible with the magnets from the MRI scanner.

    It is also suggested that you turn the stimulator off when you are operating a motor vehicle or other heavy equipment.
     
    References

  • Sakas DE, Panourias IG, Simpson BA, Krames ES. An introduction to operative neuromodulation and functional neuroprosthetics, the new frontiers of clinical neuroscience and biotechnology. Acta Neurochir Suppl 2007;97 (Pt 1):3-10.
  • Mekhail NA, Aeschbach A, StantonHicks M. Cost benefit analysis of neurostimulation for chronic pain. Clin J Pain 2004 Nov;20(6):462-8.
  • Weiner RL, Reed KL. Peripheral Neurostimulation for Control of Intractable Occipital Neuralgia. Neuromodulation 1999 Jul 18;2(3):217-21.
  • Johnstone CSH, Sundaraj R. Occipital Nerve Stimulation for the Treatment of Occipital Neuralgia-Eight Case Studies. Neuromodulation 2006 Jan 1;9(1):41-7.
  • Paicius RM, Bernstein CA, LempertCohen C. Peripheral Nerve Field Stimulation for the Treatment of Chronic Low Back Pain: Preliminary Results of Long-Term Follow-up: A Case Series. Neuromodulation 2007 Jul 18;10(3):279-90.
  • Paicius RM, Bernstein CA, LempertCohen C. Peripheral nerve field stimulation in chronic abdominal pain. Pain Physician 2006;9:261-6.
  • Burns B, Watkins L, Goadsby PJ. Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients.
    Lancet 2007 Mar 31;369(9567):1099-106.
  • Johnstone CSH, Sundaraj R. Occipital Nerve Stimulation for the Treatment of Occipital Neuralgia-Eight Case Studies. Neuromodulation 2006 Jan 1;9(1):41-7.
  • Kapural L, Mekhail N, Hayek SM, Stanton-Hicks M, Malak O. Occipital nerve electrical stimulation via the midline approach and subcutaneous surgical leads for treatment of severe occipital neuralgia: a pilot study. Anesth Analg 2005 Jul;101(1):171-4, table.
  • Magis D, Allena M, Bolla M, De P, V, Remacle JM, Schoenen J. Occipital nerve stimulation for drugresistant chronic cluster headache: a prospective pilot study. Lancet Neurol 2007 Apr;6(4):314-21.
  • Melvin EA, Jr., Jordan FR, Weiner RL, Primm D. Using peripheral stimulation to reduce the pain of C2-mediated occipital headaches: a preliminary report. Pain Physician 2007 May;10(3):453-60.
  • Weiner RL. Occipital neurostimulation for treatment of intractable headache syndromes. Acta Neurochir Suppl 2007;97(Pt 1):129-33.
  • Popeney CA, Alo KM. Peripheral neurostimulation for the treatment of chronic, disabling transformed migraine. Headache 2003 Apr;43(4):369-75.
  • Rogers LL, Swidan S. Stimulation of the occipital nerve for the treatment of migraine: current state and future prospects. Acta Neurochir Suppl 2007;97(Pt 1):121-8.
  • Thimineur M, De RD. C2 area neurostimulation: a surgical treatment for fibromyalgia. Pain Med 2007 Nov;8(8):639-46.
  • Paicius RM, Bernstein CA, LempertCohen C. Peripheral nerve field stimulation in chronic abdominal pain. Pain Physician 2006;9:261-6.
  • Stinson LW, Roderer GT, Cross NE, Davis BE. Peripheral Subcutaneous Electrostimulation for Control of Intractable Post-operative Inguinal Pain: A Case Report Series. Neuromodulation 2001 Jul 18;4(3):99-104.
  • Dunteman E. Peripheral Nerve Stimulation for Unremitting Ophthalmic Postherpetic Neuralgia. Neuromodulation 2002 Jan 1;5(1):32-7.
  • Kothari S. Neuromodulatory approaches to chronic pelvic pain and coccygodynia. Acta Neurochir Suppl 2007;97(Pt 1):365-71.
  • Slavin KV. Peripheral nerve stimulation for neuropathic pain. Neurotherapeutics 2008 Jan;5(1):100-6.
  • Slavin KV, Colpan ME, Munawar N, Wess C, Nersesyan H. Trigeminal and Occipital Peripheral Nerve Stimulation for Craniofacial Pain: A Single-institution Experience and Review of the Literature. Neurosurg Focus 2006;21(6).
  • Yakovlev AE, Peterson AT. Peripheral Nerve Stimulation in Treatment of Intractable Postherpetic Neuralgia. Neuromodulation 2007 Oct 27;10(4):373-5.
  • Rauchwerger JJ, Giordano J, Rozen D, Kent JL, Greenspan J, Closson CW. On the Therapeutic Viability of Peripheral Nerve Stimulation for Ilioinguinal Neuralgia: Putative Mechanisms and Possible Utility. Pain Pract 2008 Jan 18.